Sure thing. What I consider essential for overnighting is a flat surface for sleeping bag or futon, minifridge or ice box, and a small induction cooktop. The only integration I care about there really is the bed surface so that I can keep it remove/stowable and only set up when desired. Tool-wise, I've got light carpentry tools, some power tools, and miscellaneous stuff like computer, soldering iron, and test equipment. I'm considering how feasible it is to store everything along the sides like cabinets, with a shelf near window level to support either bed or work surface without it getting too crowded. Yes, I wanted the standard roof for other practical reasons.
radin2son, ventilation is a good point. I'd be curious to see examples you mention. Off the top of my head one of the rear windows seemed like a place to start: replace with steel panel, add fan/other equipment potentially, and mount without cutting into the existing body.
Any thoughts on the rear seat rails? That's going to be my weekend brainstorm which should most likely be posted elsewhere.